Thyroid hormone resistance is a rare condition where body tissues do not respond properly to thyroid hormones (T4 and T3), even though the blood levels of these hormones are high. Because the cells “ignore” part of the hormone signal, the Read More …

Hyperthyroxinemia means “too much thyroxine (T4) hormone in the blood.” Thyroxine (T4) is the main hormone made by the thyroid gland in the neck. In this condition, the blood test for T4 is higher than the normal reference range. Sometimes Read More …

Lambert–Eaton myasthenic syndrome (LEMS) is a rare autoimmune disease that affects the place where the nerve meets the muscle, called the neuromuscular junction. In LEMS, the immune system makes antibodies that attack voltage-gated calcium channels on the nerve ending. Because Read More …

Lambert–Eaton myasthenic syndrome (LEMS) is a rare autoimmune disease that affects the place where nerves talk to muscles, called the neuromuscular junction. In LEMS, the immune system makes antibodies that attack special “gates” (P/Q-type voltage-gated calcium channels) on the nerve Read More …

Hoffmann syndrome is a rare muscle disease that happens in adults with long-standing, untreated or poorly treated hypothyroidism (low thyroid hormone). In this condition the muscles, especially in the calves, look big and strong from the outside (pseudohypertrophy), but they Read More …

KDSS syndrome is usually short for Kawasaki Disease Shock Syndrome (KDSS). It is a rare but very serious form of Kawasaki disease, which is an illness that causes strong inflammation of small and medium blood vessels in the body, especially Read More …

Hypothyroid myopathy is a muscle disease that happens when the thyroid gland is underactive and does not make enough thyroid hormone. Thyroid hormone helps muscles use energy, contract, relax, repair themselves, and clear waste products. When hormone levels are low Read More …

Pickardt syndrome (also called Pickardt–Fahlbusch syndrome) is a very rare hormone problem where the connection between the brain’s control center (the hypothalamus) and the front part of the pituitary gland is damaged. This connection is a small stalk with tiny Read More …

Thyroid dyshormonogenesis is a group of rare genetic problems where the thyroid gland is present (often normal or enlarged) but cannot make thyroid hormone properly. The main issue is not in the size or position of the gland, but in Read More …

Van Wyk-Grumbach syndrome is a rare condition seen mainly in children who have severe, long-standing hypothyroidism (very low thyroid hormone). In this syndrome the child shows signs of early puberty and enlarged ovaries or testes, even though the thyroid gland Read More …

Euthyroid sick syndrome (also called non-thyroidal illness syndrome or sick euthyroid syndrome) happens when thyroid blood tests look abnormal during a serious illness, but the thyroid gland itself is not damaged. In this condition, the body changes the way it Read More …

Myxedema coma is a very severe, life-threatening form of hypothyroidism, where the thyroid hormone level becomes so low that the body can no longer keep basic functions stable. In this condition, the brain, heart, lungs, kidneys, and other organs start Read More …